We are studying and developing biosensing techniques in order to analyze and monitor simply and easily biological phenomena such as DNA recognition events, antigen-antibody reaction and cell functions in vitro by use of functionalities of materials such as semiconductor. Particularly, we focus on a direct detection of ions or ionized molecules with charges, because most of biological phenomena are closely related to ionic or ionized molecular behaviors such as sodium or potassium ions through ion channel at cell membrane which are based on cell-cell communication for example, and DNA molecules also have intrinsic molecular charges based on phosphate groups. In order to detect directly ion or molecular charges, we would like to propose semiconductor-based biosensing devices based on the principle of field effect.

1. *Toshiya Sakata, [Review Article] “Signal transduction interfaces for field-effect transistor-based biosensors” Communications Chemistry, 7, 35, (2024), 134239.
2. *Toshiya Sakata, Shoichi Nishitani, Akiko Saito, Yuta Fukasawa “Solution-gated ultrathin channel indium tin oxide-based field-effect transistor fabricated by one-step procedure that enables high-performance ion sensing and biosensing” ACS Appl. Mater. Interfaces, 13, (2021), 28569-38578.
3. *T. Sakata [Perspective] “Biologically coupled gate field-effect transistors meet in vitro diagnostics” ACS Omega, 4(7), (2019), 11852-11862.