FACULTY/LAB

Mitsuru NaitoLecturer

Telephone
+81-3-5841-7124
E-MAIL
naito[at]bmw.t.u-tokyo.ac.jp
* In your correspondence, please replace [at] with "@" in the above email address.
Laboratory
http://www.bmm.t.u-tokyo.ac.jp/index-e.html
Research Field
Biopolymer, Intelligent polymer, Polymer-based nanomaterial, Bioimaging, Gene therapy, Regenerative medicine, Biodegradable polymer

Research

We have developed synthetic polymer-based intelligent biomaterials that interact with our body or biomolecules to exhibit new functions. By integrating biopolymers, synthetic polymers, and inorganic materials, we are engaged in creating new biomaterials mainly for medical applications through collaboration between different fields of medicine, engineering, and pharmacology. Our research interests are as follows:

– Intelligent materials that respond to external stimuli

– Imaging technology to visualize intracellular metabolism

– Diagnostic and therapeutic techniques via systemic blood circulation

– Anti-aging for realization of a healthy and log-lived society

– Eco-frendly synthetic polymers

Selected Publications

  1. Naito*, Y. Watanuki, K. Toh, J. Yum, B. S. Kim, K. Taniwaki, S. Ogura, H. Ishida, M. Cho, H. Chaya, K. Miyajima, Y. Yamasaki, K. Osada, K. Minegishi, Y. Aoki, K. Miyata*. “Size-tunable PEG-grafted copolymers as a polymeric nanoruler for passive targeting muscle tissues” J. Control. Release, 347, 607–614 (2022)
  2. Naito, H. Chaya, K. Toh, B. S. Kim, K. Hayashi, S. Fukushima, T. Nagata, T. Yokota, K. Kataoka, K. Miyata*. “Structural tuning of oligonucleotides for enhanced blood circulation properties of unit polyion complexes prepared from two-branched poly(ethylene glycol)-block-poly(L-lysine)” J. Control. Release, 330, 812–820 (2021)
  3. Naito, Y. Otsu, R. Kamegawa, K. Hayashi, S. Uchida, H. J. Kim, K. Miyata*. “Tunable nonenzymatic degradability of N-substituted polyaspartamide main chain by amine protonation and alkyl spacer length in side chains for enhanced messenger RNA transfection efficiency” Sci. Technol. Adv. Mater., 20 (1) 105–115 (2019)
  4. Naito, N. Yoshinaga, T. Ishii, A. Matsumoto, Y. Miyahara, K. Miyata*, K. Kataoka*. “Enhanced intracellular delivery of siRNA by controlling ATP-responsivity of phenylboronic acid-functionalized polyion complex micelles” Macromol. Biosci., 18 (1) 1700357 (2018)
  5. Naito, T. Ishii, A. Matsumoto, K. Miyata, Y. Miyahara, K. Kataoka*. “A phenylboronate-functionalized polyion complex micelle for ATP-triggered release of siRNA” Angew. Chem. Int. Ed., 51 (43) 10751–10755 (2012)

Back to FACULTY/LAB