Research Objective
The biointerface is created when biomolecules, proteins, viruses or cells contact solid surfaces such as inorganic, synthetic polymer or bio-inspired materials. The aim of our study on biointerface science is to understand and control the behaviors of such biological entities on the material surfaces. We are developing highly functional medical devices for artificial organs, medical diagnoses and regeneration medicine by design of the biointerface.

Subjects of Research　
Development of biocompatible biointerfaces based on bioinspired materials for applications in biodevices
Development of highly sensitive immunoassay and cell separation device by use of polymeric microfiber
Development of block copolymers and hydrogels to investigate the cell-material interactions

A. Yoshihara, R. Sekine, T. Ueki, Y. Kondo, Y. Suanga, T. N.-Hirabayashi, Y. Teramura and M. Takai, Rapid and highly efficient capture and release of cancer cells using polymeric microfibers immobilized with enzyme-cleavable peptides, Acta Biomater., 67, 32-41, (2018).
K. Kushiro, T. Yaginuma, A. Ryo and M. Takai, Differences in Three-Dimensional Geometric Recognition by Non- Cancerous and Cancerous Epithelial Cells on Microgroove-Based Topography, Sci Rep, 7, (2017)
T. Azuma, Y. Teramura, and M. Takai, Cellular Response to Non-contacting Nanoscale Sublayer: Cells Sense Several Nanometer Mechanical Property, ACS Appl. Mater. Interfaces, 8, 10710-10716, (2016).