Yuichi Yamasaki Associate Professor
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+81-3-5841-7145 |
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+81-3-5841-7139 |
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yamasaki[at]bmw.t.u-tokyo.ac.jp
* In your correspondence, please replace [at] with "@" in the above email address. |
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http://www.bmw.t.u-tokyo.ac.jp/english/index.html |
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biophysics, DNA conformation, DNA condensation, polymeric micelle, gene delivery |
Research
The major research subjects of our laboratory are design and characterization of novel biofunctional polymeric materials for the drug delivery and gene delivery systems. In particular, non-viral gene delivery systems are attracted much attention as a promising therapy. My research interest is mainly focused on the conformational change of DNA, i.e., DNA condensation. Upon charge nuetralization, DNA collapses into a condensed small particle, which is suitable for both delivery and internalization into cells. Therefore, this phenomenon is treated as the first important step for developing gene delivery systems.
主要研究論文
K. M. Takeda, Y. Yamasaki, A. Dirisala, S. Ikeda, T. A. Tockary, K. Toh, K. Osada, K. Kataoka: “Effect of shear stress on structure and function of polyplex micelles from poly(ethylene glycol)-poly(L-lysine) block copolymers as systemic gene delivery carrier”, Biomaterials 126 (2017) 31-38.
W. Kim, Y. Yamasaki, W. -D. Jang, and K. Kataoka: “Thermodynamics of DNA condensation Induced by poly(ethylene glycol)-block-polylysine through polyion complex micelle formation”, Biomacromolecules, 11 (2010) 1180-1186.
W. Kim, Y. Yamasaki, and K. Kataoka: “Development of the fitting model suitable for an isothermal titration calorimetric curve of DNA with cationic ligands”, J. Phys. Chem. B, 110 (2006) 10919-10925.