Toshiya Sakata Associate Professor

Research

We are studying and developing biosensing techniques in order to analyze and monitor simply and easily biological phenomena such as DNA recognition events, antigen-antibody reaction and cell functions in vitro by use of functionalities of materials such as semiconductor. Particularly, we focus on a direct detection of ions or ionized molecules with charges, because most of biological phenomena are closely related to ionic or ionized molecular behaviors such as sodium or potassium ions through ion channel at cell membrane which are based on cell-cell communication for example, and DNA molecules also have intrinsic molecular charges based on phosphate groups. In order to detect directly ion or molecular charges, we would like to propose semiconductor-based biosensing devices based on the principle of field effect.

主要研究論文

S. Nishitani and T. Sakata: “Polymeric Nanofilter Biointerface for Potentiometric Small-Biomolecule Recognition”, ACS Appl. Mater. Interfaces, 11 (2019) 5561–5569.
H. Satake, A. Saito, and T. Sakata: “Elucidation of interfacial pH behaviour at cell/substrate nanogap for in situ monitoring of cellular respiration”, Nanoscale, 10 (2018) 10130–10136.
T. Kajisa, W. Li, T. Michinobu, and T. Sakata: “Well-designed dopamine-imprinted polymer interface for selective and quantitative dopamine detection among catecholamines using a potentiometric biosensor”, Biosensors and Bioelectronics, 117 (2018) 810–817.