Aya Mizutani Akimoto Associate Professor
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+81-3-5841-8844 |
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+81-3-5841-8844 |
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akimoto[at]cross.t.u-tokyo.ac.jp
* In your correspondence, please replace [at] with "@" in the above email address. |
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http://cross.t.u-tokyo.ac.jp |
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surface science for hydrogels, polymer surface design, biomaterials, interaction between materials and cells, regenerative medicine, developmental biology |
Research
Hydrogel is paid attention as a cell fate manipulating biomaterial for realization of the Regenerative Medicine. Now, what an important thing to control interaction between hydrogels and cells is quantitative understanding of their interface. Based on this idea, we are currently focusing on several to tens nm regions of hydrogel surfaces, i.e. interfaces between gel phases and water phases. Our researches are classified into 3 categories, "evaluating, designing, and applying hydrogel surfaces". The feature of our researches is super-interdisciplinary fusion from polymer physics, synthetic chemistry to developmental biology and regenerative medicine. Gathering the knowledge obtained from these researches, I aim to develop a novel "surface science for hydrogel" field and contribute to the next-generation medicine.
主要研究論文
K. Matsukawa, T. Masuda, Y. Kim, A. M. Akimoto*, and R. Yoshida*: “Thermoresponsive surface-grafted gels: Controlling the "bulk" volume change properties by "surface" localized polymer grafting with various densities”, Langmuir, 33 (2017) 13828-13833.
E. Hasuike, A. M. Akimoto* (co-first), R. Kuroda*, K. Matsukawa, Y. Hiruta, H. Kanazawa, and R. Yoshida*: “Reversible conformational changes in parallel type G-quadruplex structure inside a thermoresponsive hydrogel, Chem. Commun.”, 53 (2017) 3142-3144.
R. Tamate, K. Takahashi, T. Ueki, A. M. Akimoto*, and R. Yoshida*: “Self-assembly of thermo-responsive hydrogels via molecular recognition toward a spatially organized coculture system”, Biomacromolecules, 18 (2017) 281-287.
K. Matsukawa, T. Masuda, A. M. Akimoto*, and R. Yoshida*: “A surface-grafted thermoresponsive hydrogel in which the surface structure dominates the bulk properties,” Chem. Commun., 52 (2016) 11064-11067.