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| Design of novel biofunctional materials to produce
revolutionary medical nanodevices that facilitate clinical
cell therapy, thereby contributing to realization of the
futuristic medical system. Cell therapy,
nanobiotechnology- and nanobioengineering-based
medicine that is aimed to control the cellular function
and fate in a desirable manner, should be the key to
success in the treatment of intractable diseases and tissue
engineering. Thus, there is recently a strong impetus to
the development of funcitonal nanodevices that promote
cell differentiation at the desired site or deliver
therapeutic agents such as drugs and genes to the
targeted cells. We develop supramolecular “smart”
nanocarriers including polymeric micelles, polymeric
vesicles and multi-layered nanoparticles, through the
self-assembly of artificial and natural materials, and
carry out the nanocarrier-mediated cell therapy by
facilitating the translation of basic achievements into
clinical applications. |
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| A. Kishimura, A. Koide, K. Osada, Y.Yamasaki,
K.Kataoka: “Encapsulation of myoglobin in PEGylated
polyion complex vesicles made from a pair of oppositely
charged block ionomers: a physiologically available
oxygen carrier”, Angew. Chem. Int. Ed. 46(32) (2007)
6085-6088
Y. Lee, S. Fukushima, Y. Bae, S. Hiki, T. Ishii, K.
Kataoka: “A Protein Nanocarrier from Charge-
Conversion Polymer in Response to Endosomal pH”, J.
Am. Chem. Soc. 129 (17) (2007) 5362-5363
M. R. Kano, Y. Bae, C. Iwata, Y. Morishita, M. Yashiro,
M. Oka, T. Fujii, A. Komuro, K. Kiyono, M. Kamiishi,
K. Hirakawa, Y. Ouchi, N. Nishiyama, K. Kataoka, K.
Miyazono: “Improvement of cancer-targeting therapy,
using nanocarriers for intractable solid tumors by
inhibition of TGF-beta signaling”, P. Natl. Acad. Sci.
USA. 104 (9) (2007) 3460-3465 |
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