Kazuhiko Ishihara Professor
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|polymer biomaterials, MPC polymer, biointerface, cell-materials interaction, artificial organs, cell-engineered device|
We are developing novel polymer biomaterials based on molecular design with strong inspiration from the surface structure of cell membrane. That is, the polymers with phospholipid polar group in the side chain, 2-methacryloyloxyethyl phosphorylcholine (MPC) polymers are synthesized. The MPC polymers can inhibit surface-induced thrombus formation effectively, even when they contact with blood in the absence of anticoagulant. This phenomenon is due to reduction of plasma protein and suppression of denaturation of adsorbed proteins. As the molecular structure of the MPC polymers is easily designed by changing monomer units and composition, they can apply to the surface modification of artificial organs and biomedical devices. In fact, implantable artificial heart and artificial hip joint with the MPC polymers have been approved already and applied to patients. We are also investigating photoinduced surface treatment on the substrate for making all-plastic artificial organs. Moreover, to contribute the progress of regenerating medicine using cells, the cytocompatible MPC polymer hydrogels are prepared. It is expected to establish new cell-treating technology in the bioengineering field.
B. Cheng, Y. Inoue, and K. Ishihara: “Surface functionalization of polytetrafluoroethylene substrate with hybrid processes comprising plasma treatment and chemical reactions”, Colloid Surf B: Biointerfaces 173 (2019) 77-84.
H. Oda, and K. Ishihara, “Determination of association constants between water-soluble phospholipid polymer bearing phenylboronic acid group and polyol compounds for reversible formation of three-dimensional networks ”, React Funct Polym. 135 (2019) 113-120.
Y. Murahashi, S. Tanaka, K. Ishihara, Y. Okamura, T. Moro, T. Saito, “Multi-layered PLLA-nanosheets loaded with FGF-2 induce bone regeneration in critical-sized mouse femoral defects”, Acta Biomater 85 (2019) 172-179.