Kazuhiko Ishihara Professor

TEL +81-3-5841-7124
FAX +81-3-5841-8647
ishihara[at]mpc.t.u-tokyo.ac.jp

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研究室 http://www.mpc.t.u-tokyo.ac.jp/index_E.html
研究分野 polymer biomaterials, MPC polymer, biointerface, cell-materials interaction, artificial organs, cell-engineered device

Research

We are developing novel polymer biomaterials based on molecular design with strong inspiration from the surface structure of cell membrane. That is, the polymers with phospholipid polar group in the side chain, 2-methacryloyloxyethyl phosphorylcholine (MPC) polymers are synthesized. The MPC polymers can inhibit surface-induced thrombus formation effectively, even when they contact with blood in the absence of anticoagulant. This phenomenon is due to reduction of plasma protein and suppression of denaturation of adsorbed proteins. As the molecular structure of the MPC polymers is easily designed by changing monomer units and composition, they can apply to the surface modification of artificial organs and biomedical devices. In fact, implantable artificial heart and artificial hip joint with the MPC polymers have been approved already and applied to patients. We are also investigating photoinduced surface treatment on the substrate for making all-plastic artificial organs. Moreover, to contribute the progress of regenerating medicine using cells, the cytocompatible MPC polymer hydrogels are prepared. It is expected to establish new cell-treating technology in the bioengineering field.

主要研究論文

K. Ishihara, Y. Fukuda, T. Konno, and Y. Inoue: “Molecular integration on phospholipid polymer-coated magnetic beads for gene expression analysis in cells”, React. Funct. Polymers 119 (2017) 125-133.
S. Chantasirichot, Y. Inoue, and K. Ishihara: “Introduction of functional groups to reactive ABA block-copolymers composed of poly(2-methacryloyloxyethyl phosphorylcholine) and poly(glycidyl methacrylate) for spontaneous hydrogel formation”, Polymer 123 (2017) 100-106.
S.-H. Chen, Y. Chang, and K. Ishihara: “Reduced blood cell adhesion on polypropylene substrates by a simple surface zwitterionization”, Langmuir 33 (2017) 611-621.